Doctor's Formulas Dietary Supplement D-Mannose 500mg 30 capsules

Food supplement for immediate and effective protection against urinary tract infections.

Mannose is a simple carbohydrate found in fruit and it is also produced by the human body, but in small quantities. It is absorbed in less than 30 minutes in the peripheral organs and then passes through the urinary system and is excreted. It cannot be converted into glycogen, therefore, it is not stored in the body. It adheres to lectins and thus prevents the attachment of pathogenic organisms to the walls of the bladder.

Action

Its mechanism of action is expressed through inhibition of adhesion of the surface protein FimH. By direct binding of FimH to D-mannose bound to a carrier protein, which is responsible for receptor specificity.

The 1st adhesion step involves the mannose-sensitive binding of FimH to the epithelium. The bladder wall is coated with various mannose-glycosylated proteins, such as the Tamm-Horsfall protein (THP) that directly interferes with the adhesion of microbes to the mucosa. Tamm-Horsfall protein (THP) can bind to E. Coli by a specific bond, which can be inhibited by exogenous D-mannose.

Notification number of the National Organization for Medicines (EOF): 47421 / 27-04-2018

The notification number in the National Organization for Medicines (EOF) does not serve as an authorization for marketing by the EOF.

HOW TO USE

1 - 2 capsules daily